I am not sure about the Wacom tablet,,,, I run an XP machine with Poser 5 and a W2K machine with Poser - both machines have Nividia T4 and both work great. Poser does not support Open GL so unfortunately Poser won't be taking advantage of the power of your new card. Regardless of the open GL though your new card will help on the redraw rate and being able to support millions of colors, which will be very beneficial. In addition your new card will probably support dual monitors. This is will make a huge difference as you can move most of P5 interface windows around. The only annoying factor is P5 has some of the menus (i.e. "are you sure you want to delete") that are programmed to pop up in the middle of the screen, these windows will show up between the two monitors even if you set your Nview settings to display windows on a particular monitor. Besides that - I am sure that you have read tons of criticism about P5. P5 still has some small issues that are lingering but as a program P5 Rocks. P5 has an incredible new material room that is based on the same system the Pixar uses. The New Parameters and Properties pallet make it so easy to move, delete and organize all your dials. The new editing tools make a huge difference in how fast and accurate you can pose your figures. The cloth room is very easy to simulate draping cloth and wind blown flags, I have not quite mastered dynamic clothing yet but I am sure it rocks as well. Same goes for the Hair and Face room. With the new FireFly ray trace render mixed with a 3.05Gig you will love it. Lately I use P5 three times as much as I use Maya, that's how cool it, is.