I think I know what you mean. When you first start it, the work area screen is overly large, and covers all your tools. Instead of centering, it sort of sprawls across the right side of the work area. The resolution of your PC makes no difference. I run 1024x768 on my PC. Not sure why the silly thing does this. What I figured out to do (since there seems to be no way to move the work area to center it), was to select "window" from the menu, go to the bottom and select "document window size". Select a size that places the thing in the center. I use either 397x388, with the largest being 640x480. That way you can get at all your tools. You should be able to set this as a default under general preferences so the next time your start it you won't have to make the adjustment again. When you get ready to render a final image, you can set your render preferences to render to a new window and set your image size accordingly. That's when the PC resolution size will be important.