Attached Link: http://personal.cfw.com/~tkprit/page/leak.html

Do you de-frag your harddrive regularly? when working with files that large, a harddrive can become seriously fragmented very quickly. I routinely defrag my computer once a week minimum (I'm running an AMD 2400+ proc, with the same anount of memory as you and 140GB of disk space on WinXP Home). If your drive is badly fragmented it can take a long time for your system to find enough space to save your files You also might want to try running a dianoatic on your machine (SiSoft Sandra or something like that) to see if you're having a problem with "memory leaks" when you're in Photoshop. Since you are running Win2K the attached article link may be of some use I run some pretty large files myself with multiple layers (sometimes as many as 50-60 layers at 300-400 MB) and have never had PS take longer than a minute or so to save a file unless I was running some sort of memory hog prior to opening PS and hadn't rebooted the machine or my system needed de-fragging.