Soth, I think he/she means the seams on the figure, not the actual texture itself. Making a seamless tile will only work on some geometries (ones mapped with all the seams at the edges of the picture frame, like a P4 box). I don't have a copy yet, but from what I hear zBrush will let you paint directly onto the model in 3D space. I want a copy for that reason. Deep Paint 3D does this too, and is its primary reason for existing so I hear. Otherwise, nope, no tricks, just a lot of sweat, hair-pulling and screaming. UVMapper Pro will help as you can copy-paste the image directly onto the 3D view and work faster (with UVMapper Pro Free Demo you can load up the texture as a BMP on a 3D view but you have to save a copy as BMP each time)