From the MIMIC2 readme (without typo corrections):

Before you launch Mimic2 or Mimic2 Pro for the first time, you will be asked to locate Poser application file (Poser.exe). I you choose not to link to Poser, you will be prompted each time you launch Mimic to locate the Poser application.

Of course, the same "rename a poser.txt to poser.exe cheat" should work the same with MIMIC2 as MIMIC1 if you'd prefer.