I have two wacoms, one 4x5 at work and the 8 x 6 at home, and work with them extensively. I can honestly say that I prefer the smallest one, as mentioned above you only need to move your wrist to draw. It also occupies less real estate on your desk, it may not sound important but when you have a keyboard, a mouse, a manual, your coffee cup, a couple of CD's, papers,(a cat!) etc... it quickly becomes an issue. The small Intuos is just great.

Dominique Digital Cats Media