Larger file sizes make ALL programs unstable, it's just a given. Maybe try splitting up the elements in the scene into separate scenes and rendering and compositing them accordinly. I can tell you from experience that large file sizes bogging down a program is definately not unique to Vue. I'm using Autocad 2002 at work and am currently working with a model that is at 63 megs (dwg format) on a 3ghz dual processor system that's brand new, and have bombed out of it on several occasions just trying to rotate the view too quickly. Autocad is an industry standard software (a very expensive one I might add) and I would be highly surprised if Vue (a $500 program) was NOT unstable with a 100mb scene file. Sorry for the rant, just getting a little tired of seeing "vue sucks because of this..." and vue sucks because of that..."