Here's a cropped detail from the 1500 x 2500 version, which I did AFTER I did the original piece when the client asked for a larger version to put on a poster or a Cafepress t-shirt. Because the text was not rasterized, it kept its smoothness, and because each part of the lizard was a path on a layer, the edges remained sharp. If you look really closely, yeah, you can see slight pixelation in the green of his skin. If I wanted to, I could put a little gaussian blur on it to smooth it out, but the edges will remain sharp because they're made by paths. Even the black outline will remain sharp because it's rendered with a style stroke (that I had to tweak to make it wider after the enlarging, of course; the pixel size stays the same otherwise). As I mentioned above, there's some blurring of the background texture, but since that's not the focus of my image, I didn't care. So there you go -- one example of successfully enlarging an image in Photoshop without much loss of quality. If I could remember the colorist's name, I'd point to an artist who uses the comics art style enlarging technique I mentioned in my first post.