I'm thinking about getting one of the various Runtime organizers out there. Like Poser Product Manager:

http://market.renderosity.com/softgood.ez?ViewSoftgood=21087

Or PInstall:

http://market.renderosity.com/softgood.ez?ViewSoftgood=7054

Seems like they would make slimming down your Runtime(s) easier, since they know what goes with what, and allow you to install and uninstall archives. (So you could uninstall and archive products that aren't used often, or are only used at certain times of year.)