sure, it runs well on my dual 64s. i don't think it has any boost because of it yet, but if poser6 comes out able to take advantage of 64 bit processors, you'll be sailing. very few things right now take advantage of 64 bit processors, but time is linear. WE'RE MOVING TOWARD THE FUTURE, NOT THE PAST. take advantage while you build this computer, not the next one. :)