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Think about focal point - what do you want your viewer to look at to help them understand the visual story? Focal points usually have more contrast, texture and detail. You can use lighting to pick out a focal point or to obscure or soften other areas of the composition. Images can have one or more focal points of varying importance.

Use unusual angles or points of view to present your image. Look for items in the image that can be used as a framing device to enhance the composition.

One of my pet peeves with some digital art is that everything is rendered to the same degree all over the picture plane. If you look at paintings by master artists you will see that how an artist has chosen to emphasize certain areas of the rendering to lead the viewer's eye. Many areas will be rendered very loosely and painterly away from the center(s) of attention.