You need to leave the main runtime in the Poser folder. But you don't have to put anything in it. Except the !DAZ folder, if you're using any generation 3 DAZ figures. The problem with DAZ's morph injected figures is kind of odd. Most people find they have to have the !DAZ folder in the main Poser runtime. But a few people have no problem at all. If you find it suddenly takes forever to inject the morphs, the problem is likely the !DAZ folder.