Don makes a good point about meshes .. but even the latest Unimesh (M3, V3, David, Steph3 etc) leaves a lot to be desired. The problem is mainly the base of the thumb. Take the sign for the number 4, shown above. I can touch the tip of my thumb against the base of my little finger without any effort. Poser figures (so far) can't. As a result, getting the right conjunctions of fingers and thumb in hand poses requires unnatural twists and sideways movements of the fingers. The other anatomical error is that Poser fingers bend where the finger meets the main body of the hand. But, if you bend your own hand, you'll see that actually it's your palm that bends where you've got those creases in the skin running transversely across your palm. Look at your hand sideways on and notice where your knuckles are.