Using AVG, Spybot and a harware firewall in the brodband router (used ZoneAlarm before that). No problems at all. Not that nothing ever get in. Every now and then when I run Spybot it finds something. Probably because the spyware has changed a little so it not could be identified by spybot. I'm running Iexplorer because of pure lazyness. On the computer I use for sending emails I'm running Opera instead as the spamfilters works very well. When I surf the net and get several popups, get sent to pages that tries to sell something, my startpage changes or I get told to get some anti spyware (one wonder if it's the same people making the spyware and the removers) it's time to run Spybot. I have never had anything making any real damage to my computer.