If money is no object then go with the Intutios as they apparently have more capabilities. From the Wacom site the Graphire 3 starts at $99.95 for the 4 x 5 and the Intutios starts at $219.95 for the 4 x 5. Also depends on which size of tablet you want. Graphire 3 has 2 sizes (4 x 5 and 6 x 8) where Intutios also has the 9 x 12 and larger tablets. I am still on my original Graphire tablets (both 4 x 5) which are now 5 years old. I wouldn't be without my tablets.