I've been habitually rendering images at 1600x1600 (matches the width of my monitor) I've just started using face_off's Real Skin Shader and even node heavier shader variants with raytraced lights, displacement maps, reflection and refraction. Never had any rendering problems other than Firefly artifacts caused by floating point underflows due to scene scale. A few weeks ago I switched from using a bucket size of 128 up to 256 and noticed substantial render time improvements, but also render crashes on denser scenes. Going to a smaller resolution 1200x1200 allowed these renders to work, but I finally gave in and set the bucket size back to 128 and now I have no problem at the 1600x1600 resolution again.

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