"Sent to at least 2,000 ad agencies in US and Europe with your contact details..." Is this solicited or unsolicited? If this was an established publication, with a good reputation, I could certainly understand a submission fee. If it is solicited, then I might even consider it if I were ready to take on work. If this will be unsolicited mailings, then I can't say I'd be likely to pay for submission in a publication that could very well end up in 1,997 "circular files". If it were being sent to 20,000 or more agencies,unsolicited, the odds would be better, making the fee worthwhile. Perhaps it might be wiser to do as Taschen did, with "Digital Beauties", and solicit specific artists. No submission fee, but one or two hard copies of the book would probably be sufficient. This seems more like a cattle call. Do auditions usually require a fee?