A couple of points: scanners scan in RGB-- CMYK is a generated format that's bigger and typically is targetted at the color profile of a specific output device. So you should be saving RGB for future use, and convert to CMYK when and if you need to print from it again. The scanner itself doesn "see" CMYK, so this info is "invented" by the conversion software-- you gain nothing saving it this way. If your scanner is truly scanning at 16 bits, as opposed to software interpolating 8 bits to 16, then you should save this way, because its more information. A number of digital asset managment systems will automatically produce reduced size versions of your source files and place them in designated places. . .Cumulus, Extensis Portfolio, PhototoWeb --- there are many solutions for the problem of storing and repurposing files at multiple resolutions, formats, whatever. . .search on "digital asset management" and you'll find many systems. . .