god yes! NTFS is a big jump in speed. I certainly noticed it in most of my apps. My backup drive is still FAT32 and i had it in a few weeks ago. Also, never underestimate a fast harddrive RPM and disk cache either. RAM i'm not so sure about, i went from 2 gigs to 4 gigs and Poser didn't seem to care at all. Pretty bummed about that.