I never had that, not on Mac nor on Windows. Lucky me probably. But what i had several times was that Vue is not reacting to the mouse anymore - especially with Wacom tablets. Sometimes a little trick worked for me. To make the Vue window small and "reopen" it again. To give it a refresh for the display part of Vue. Maybe your Vue was in an unstable status already before your problem appeared. So maybe it is an option to always close and restart Vue before doing a long renderer. To be sure it not in a wild memory status.

One day your ship comes in - but you're at the airport.