Thanks to all for the suggestions. I've found a workable solution, without reformatting my hard drive. To Acadia: OUCH! First, I created a second user on my computer, called Poser User, that I log in as whenever I want to use Poser. Second, I set McAffee Virus Scan to "disable" at boot up, so it doesn't take up memory. I launch Poser, which takes about a minute to boot. Then I exit Poser and launch it again. This time, Poser starts in about 15 seconds, because all the TSRs are in memory. Voila! No more loading problems. A bit of an inconvenience, I know, but one that I can live with. Hope this helps others as well.