Yeap, I've had that same problem with some of my really big files - as soon as you change a texture or delete something, you can no longer save the file. I'm not sure if the file is corrupt, or if bryce is having too much trouble dealing with the changes in its temporary spool file it makes when it runs out of ram when you delete things. Try deleting the most recent things you added to your scene (only one at a time) and then saving that scene less the one object. No idea if that'll work, but its all I can think of at the moment.

Dreams are just nightmares on prozac...
Digital WasteLanD