The holds are too solid. It looks robotic. Moving holds is what she needs. Don't let her stop moving for more than a frame or two. On the frames where you have her not moving right now, instead you should have her moving slowly. She should be easing into the next pose. You should be thinking about how her emotion affects her speed, as well as her body language. You are going to have a lot of hard work ahead of you if you want to get this done. Take a look at the book, "Stop Staring! Facial Modeling and Animation Done Right" by Jason Osipa. The book is full of great instruction on easy lip synching that looks far better than automated lip synch, as well as eye & eyebrow animation. It's written for Maya, but there is a lot of great, non program specific information in it, but there's also a lot of stuff in there that Poser can't do, like pose slider driven bump maps(For wrinkles that really wrinkle), two-dimensional pose sliders (They really do make things so much easier), and custom interfaces. Still, there is a lot that will help add some polish to your animation. An important thing to remember is that the level of detail for your animation must be consistent with the level of detail that you put into everything else. The more realistic you make the world, the more accurate your animation is going to have to be.