Hmm... only in Photoshop.

I was speaking of the system scratch disk Jason. I'd check that one next.

Also, when the problem appears, does it do it when you open, after performing a certain task???

Have you installed any Photoshop Plug-Ins.

Update your virus definitions and run it to see if there is an infection.

Yank My Doodle, It's a Dandy!