intuos - 1024 levels of pressure, 4 programmable hotkeys (4 on each side - they'll have the same functions as either side - they're just in BOTH corners in case you're a righty or lefty) and a slider-bar so you can "skim" your finger up or down it to zoom in or out. More of a custom contoured pen - like an ergonomic grip. Mouse has side-buttons (as well as being a 2 button with scroll wheel) - like for going/paging forward and backwards on the web. Graphire4 - 512 levels of pressure (like I said, can't tell the difference between mine - they both feel the same to me!), only 2 keys (and they're kinda like side-keys on a mouse) and a roll-bar for scrolling up and down. Standard tube-ish like pen - not ergonomic, but feels fine to me. Mouse has no side-buttons - just 2 buttons with scroll wheel. Oddly, I don't use either tablet's mouse - just the regular one for each computer. The Graphire is great if you're on a budget. The intuos is great for the hotkeys so - like when on Photoshop - you can keep your hands off the keyboard for hitting your Cmd/Ctrl, Shift, and Opt/Alt, and spacebar keys. The only reason to reach for your keyboard is for keystroke shortcut commands. Hope that helps- -Lew ;-)