This sounds familiar to me... May it be that you use "external binary morph targets" (You find this setting under preferences-->misc)? If so Poser will collect the morphs in an extra-file, the name is the same as your scene. As an example: If you save your scene as "My new image.pz3" you will find a "My new image.pmd" too in the same location where you saved your pz3. When I was new to those binary morph targets I deleted some of the pmd-files after rendering and when reopening the pz3 all morphs where gone, I had a standard V3 with standard clothes... But however, installing the service release 2 is a good idea, you'll get rid of a lot of problems.

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