Unfortunately not. When this happens I usually start all over, so I never found the culprit.

To start use the default settings, just adapt resistances depending on the cloth type (leather doesn't bend like satin). Don't use values too extreme, else Poser will do some really strange things. Run the simulation, check the result and adapt values till you get something which looks like it should. It helps having a fast computer and a simple scene; What I do is clothify in an empty scene, spawn a morph target, save the figure and her clothified cloth in the library, and insert it from there into the scene. Of course the simulation is lost (good thing, economizes memory), but since you have your morph it doesn't matter.

I also remember that Poser 5's Cloth Room  was a little quirky; Poser 6 was buggy, but Poser 6 SR2 is stable at last. YMMV.