You will run into issues with loading content off of DVDs, because paths are stored from the drive letter (ie, G:/Victoria3/Runtime/Geometries/DAZ/MilWom/blMilWom3.obj)

Unless the DVD with those necessary files on it was always in the drive, you would be unable to open scenes using content from any Runtimes off of the DVD. Poser may also throw errors when starting up if it can't find your DVD Runtime.

I would recommend using an external/portable hard drive rather than DVDs, and keeping the same drive letter mapped to the external drive.