If you're going to be doing a lot of manipulation, you might want to do each panel in a separate file and then import the flattened image into Photoshop.  At the very least, you shuold consider creating a separate layer group (folder) in the layers pallet for each panel.

By the way, there is a new app out that focuses ENTIRELY on drawing comics.  It's called Manga Studio.  I've been thinking of picking it up, and would if the $50 version had the automatic word baloon feature.  But, alas, that feature is only in the $299 version. :-(

Do a search for the app, or visit RuntimeDNA.  They have some info and samples online.

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