Hmm... the poser 6 with MangaStudio looks sweet. (If I had the chance to rebuy poser I'd take that deal)

But you might want to do some 3D modeling with an app with tools for it

No reason not to use just poser 6, it has toon shaders (you have to assign them to the materials).

I had to compromise with price (So far I use Vue4 D'Esprit for my Backgrounds, truespace 6.6 for my 3d modeling and poser6 for all the characterwork) once I get poser 6 down pat I'll be uploading some works.

I got all my apps through sales/upgrade specials so it was quite convienient! (ALL for Less than $400 US, likely cheaper now)

Carrara 7 Pro, Anime Studio Pro 8, Hexagon 2.5, Zbrush 4.6, trueSpace 7.6, and Corel Draw X3. Manga Studio 4EX, Open Canvas 5, WACOM Cintiq 12WX User