Billy nice topology. You have your verticies too close to each other on the corners of the mouth that is causing the pinching that I see. I think you have a great model to work with the overall flow of the polygons is great so don't ditch it. Just open up the corners of the mouth and then go at the nose. The corners of the mouth are not that sharp so open it up.

   I personally think it is a good idea to start with a masculine face. Because it allows you a bit more freedom to exaggerate the features. I tend to do my characters with less realism I find those characters going for total reslism a bit odd. I like things like Shrek and the Incredibles. A bit of style over substance.

The wit of a misplaced ex-patriot.
I cheated on my metaphysics exam by looking into the soul of the person next to me.