For indoor shots I usually use one spotlight centered but slightly offset as my main
or Key light.  This one I have set to cast shadows and the intensity is at 90%.
I tweak its location to get the shadow to fall where I want it.
Then I add a point light high and to the left of the scene as my side light.
No shadows and intensity at around 30 to 40%.  And lastly I have a fill light
low and to the right of my scene.  No shadows and also 30 to 40% intensity.

For outdoor shots I use one light set to IBL with ambient occlusion and
one spot light to cast a shadow.  I locate the spot light again depending
on where I want the shadow to fall.