Wow - gotta pick just ONE?!

I'd probably say my Nikon 24-120 VR is my most trusted and used lens in the bag for my general imaging needs (I have a Sigma 17-70 that is used often, but not nearly as much).

For my Macro needs, it's a tough choice between the Sigma 105 DG and the Sigma 180 (for the more shallow DOF look I like to get)... Probably the 105...

My 60mm Micro, 20mm, and 80-400 IS almost never come out of the bag these days - and I haven't had much time to play with the LensBaby 2.0 so it's up in the air, but kinda neat.
-Lew