As long as you backup your Runtime folder you should be safe as it is just a matter of reinstall Poser and then overwrite the runtime folder with the backup - and Bingo! all should be restored.

Just as note of interest - I either use mulitple drives or partitions and have nothing on my "C" drive apart from the operating system (in my case Windows) that way if I lose Windows - i haven't lost everything else.

I hate programs that implore me to install to "C" drive......

The supreme irony of life is that hardly anyone gets out of it alive.
Robert A. Heinlein

11th Gen Intel(R) Core(TM) i9-11900K @ 3.50GHz   3.50 GHz
64.0 GB (63.9 GB usable)
Geforce RTX 3060 12 GB
Windows 11 Pro