If you're using Photoshop, aside from resetting your Windows Virtual memory, you also have the option to Up your Photoshop Scratch Disk Usage  From Edit > Preferances >Plugins & Scratch DIsks you have the option to tell Photoshop to go to up to 4 different disks fo Virtual Memory.  By default only the first is set, to your Startup Disk, but I'm not sure if that even means the whole "C:" drive?

I did'nt hink there would then be that much a contrast from Disk to RAM??