Well.

Anyone can knock out a quick render in Poser. No biggie. No huge amount of skill involved.

The DIFFERENCE is doing a render in Poser that stands up next to some of the "Big Names".
It is possible, but it takes a LOT of skill and just as much time, if not more, because you're limited by what Poser can do.
You might end up pulling it into another program to get what you want out of it, but the END result can be as different as night and day.

I tell people I use Poser and they scoff.
Then I point them at my 2D work and they suddenly shut up.

The bias is that if it was done in Poser, it can't be good. They all go very quiet when it IS good.

And BTW - I once browsed a site advertising Maya courses and looked at the student showcases...
One of those showcases featured... V3.
Frankly, even with my limited animation experience I could have done better... in Poser.

Silke