I'm guessing that if this was made with a EF product it was probably Anime Studio.
http://www.e-frontier.com/article/articleview/1913/1/793?sbss=793 (link)

to do something like this in poser would be near impossible as the models are usually more anotomically correct in poser. More of what you would see in realism style comic books. You can check the galleries here under poser comics to find some great (and greatly talented) examples.