I don't think anyone is wanting a registry cleaner due to viruses or spyware?  I wouldn't have even thought to use one for that.  It's amazing how much stuff that's no longer needed gets left over in your registry after you uninstall an app, change hardware, or update things.  I have multiple drives, multiple partitions, and almost never install anything under Program Files.  Now I realize that there are folks who believe that you need to reformat your drive or at least re-install Windows every few months, but I've never done that.   You don't want to know how many applications I have installed over the years.  (I don't even want to know)  I certainly don't want to re-install them all the time.  A little system maintainence now and then has kept everything humming along just fine for years.  A registry cleaner (among other things) is something I use periodically to keep my systems running well without having to start from scratch every 6 months.
 

Irene-