This is a perfect place to ask, but be warned, you will get a huge variety of answer!

I'll start.

I did a comic a while back for Renderotica's magazine.  It was a huge learning experience, I might add.

There are a few things to consider.

First, if you are new, then you will need to invest time in getting to know how to set things up for a nice render in Poser.  Poses, textures and lighting are all very important considerations and the more you play with, read and learn in these areas, the better your comic will be.

But that is the first learning curve, and it does take some time investment.  I've been using Poser for going on five years now and I'm still nowhere near the best artists, but I have come a long way!

Second consideration, is complexity of scenes.  I've had panels that were so complex they took me three days to build (often painting my own textures before hand) and then another day to render.  If you are using Poser 7, you won't have to worry about a scene freezing partway into a render, but you'll still have to contend with render times.  A complex scene with multiple figures on a single core processor machine can still take 8 or more hours just to render!

Third consideration is postwork.  When I worked on my comic I took every image into Photoshop for various reasons.  Sometimes to add nifty special effects like lasers, sometime to composite more then one image together, and always to adjust contract and colour values so that in the end my comic wouldn't look like "just another Poser comic".

My post work could take anywhere from one to four hours per panel.

Then the final step is arranging pages and adding all the dialogue, balloons and so on.

Considering I have a full time job, I could realistically produce a five panel page in about a week and a half.

If I had two computers and it was my job, I think I could have done a five panel page in about three or four days.

In the end, it was a very rewarding experience, but I was using Poser 5 and I ended up with a lot of stuff that wouldn't render and I had to keep making compromises.  It made me walk away from Poser for at least half a year in frustration!

This is my experience.  I was going for as professional and original of a look as possible.  if you are just doing it for a hobby, then you can probably cut down a lot of time.  You will find it fun, but you probably won't make any money with it.

If you are looking to seriously get into making comics, I suggest getting to know your image editing software really well (for example, Photoshop)!  What you can accomplish in post production often will save you time and afford you creativity that you cannot get from renders alone.

Also, collect as many freebies as possible.  It's amazing when you are building a scene the little knick knacks you will need that you never thought of.  It is very nice that freebie artists create the things we might never buy or think about (toilet paper roll? cigar box? half eaten apple?) but that we really need to make our scenes richer.

Oh, if you are thinking for commercial purposes, though, only collect things where the artist says you can use them for commercial purposes in the readme.  I personally pass over anything that won't give commercial use privilages.  Or, you can contact the author for permission.

Anyway, good luck and when you do do something, let us all know.

Cheers!