I have Vista RC2 (not even final!) and it runs great, so does V6Infinite.

Just your graphics drivers. If you're using nvidia ones, get the new Forceware X betas. If you're using AMD/ATi, why even complain? Catalyst is stable and awesome.

And talking of DRM- if you don't touch it, it won't touch you. So much for FUD (oh wait, this is R'osity. :D)

In This Twilight- My FIRST public poser work in 2 years!
Also the reason why I endorse postwork (:D)