This is also a problem with Vista Premium.  It's a Vista wide issue.  Basically it's a role of the dice.  You have no way of know which applications require twaeking and which don't.

It does seem that most of the applications that MS has produced work in Vista.  I have been told that some people even have run a MS Game Pack for Win 3.1 in Vista.  I have no way to confirm this but it would it seems to suggest that MS apps will all run in Vista.

If you have Photoshop - I have heard quite a few reports that it just does not work in Vista.  Even versions as current as CS2.  You can get it installed but it crashed and does strange things.

From my Flim & Game Industry contacts I have been told that they have NO PLANS to go to Vista until well after the release of Service Pack 1 for Vista.  There are some that have said they will wait for a Service Pack 2 to be released before they consider installing Vista.

Vista is a real crap shoot.  If you have work and production deadlines to meet DO NOT install it.  If you are a home user and can afford the hassel go ahead and play with it.  Just beware of all of the unsupported hardware that is out there. 

I ran into this yesterday at a clients site.  A new system with Vista Home and it cannot connect to their Domian.  Problem Vista Home is INCAPABLE of a domain connection, you need th Vista Business Edition.  Also I discovered that you cannot install XP Pro on this system because there are NO DRIVERS for XP for it.   XP couldn't identify the South Bridge, onboard audio, onboard video, and the SM Bus Connector.   Take this as a warning be very very careful what you buy you could get screwed real easy.

Best of Luck.