My only single runtime goes maybe around 30Gb. The only thing that is slow is starting taking between 3-4 minutes typically. I haven't noticed any slowing in anything else. Moving thru libraries take no excess time. Starting up time doesn't bother me at all. I've organised my stuff VERY meticulously from the beginning. That also means that I have no directories that have huge amount of files in them. That may affect the thing - I have only half a dozen top hierarchies for each library palette entry. The content is then found along that path. (Example: in the character folder I have "HUMANS", under that "V2", under that, "OUTFITS", under that "HISTORICAL", under that "POSERWORLD" and under that a list of historical PW Outfits for V2. It takes only few clicks to get into any item I've ever installed this way.) So ... big single folders might be the cause of slowing things down.