Hmmmm, interesting thread.

I'm currently running Vista 64bit business edition on a Intel Duo Core (E6600) machine with Poser 7 SR1 and various other proggies with absolutely NO problems. None. Even with updates and reboots. 

No men in black suits from Microsoft (or the government) have come to take me away, my machine isn't being hijacked by every hacker known to mankind and aliens haven't landed in my backyard. 

At least not yet. :-)

i7 6800 (6 core/12 thread), 24 GB RAM, 1 gtx 1080 ti (8GB Vram) + 1 Titan X (12GB Vram), PP11, Octane/Poser plugin, and a partridge in a pear tree.

Oh, and a wiener dog!