I have Esprit and Vista x64 with 2 processors.  The problems currently are OpenGL compatibility versus Vue. 

If you are going to run the newest and Vista you have to make sure that all of the hardware and software are compatible with Vista. You can run 32 bit software under Vista, and you can change the compatibility mode to WinXP. However, not all of the hardware out there will support x64 Vista or has drivers for x64 so you should choose your system carefully… 

Currently most Vue users will tell you to stay with WinXP and upgrade when Vista is more stable. 

 

This is the place to go while deciding what you are to build. It is not 100 percent accurate, as some drivers and hardware will not work as claimed.  Go to the Manufacturers web site and get the tech specs and see if they have true x64 drivers. Some use worked-over WinXp x64 drivers that may or may not work.

 

http://winqual.microsoft.com/HCL/Default.aspx?wt_svl=10048VHa1&mg_id=10048VHb1

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