I have a multi boot ststem, using  intel Q6700(x-quad). Win 32, 64 and Vista ultimate 64. As Keenart said, drivers are hard to find for vista 64. No big issues using Vue I 6, but I find my self using xp 64 the most. It's the fastest and most stable of all three OS. Using 64 bit will also allow the use of more memory. 32bit stops at 3 gig out of the 8 GIG I have installed,