I agree with pjz99. Unless you are specifically making a comic ABOUT Poser, I would avoid using default characters (James is the real culprit here). I would also avoid using default library poses, which for anyone that has used Poser 6 or above are instantly recognisable.

If you're aiming for a short and sweet serial strip, four uniform panels is fine. If you looking at making something grander, your panels should be as dynamic as their content. Pick up any Marvel or DC comic to see what I mean. They're very rarley uniform in their composition.

As for the look, there are a number of packages available as MissNancy stated, or you could try something yourself. I've attached an image of a WIP promo shot for a strip I am currently working on. It's a private project that will see a limited run - just enough for friends and family (hence not trying to hijack your thread).

Making it enterating is a complicated task. My only suggestion would be to write what you know, and not to try and write what you think your potential audience will want. If only a select few people like it, you can call it a niche comic with an exclusive fanbase! :)

If we can hit that bullseye, the rest of the dominos will fall like a house of cards...checkmate!