No problem here, DS runs better in Vista then in XP.
The problems looks like video drive. If you use video borad from NVidia take care with the last drive because it cont use OpenGL 2.1
Openup DS and go to menu Help / About Your Video Card and looks what is the OpenGL version.
If you use a FX5XXX series from NVIdia is time to upgrade because NVidia decided to not support this chipset anymore... You still can use it with internal Vista drive but you cant get OpenGL 2.1 with this drive. I am using the drive version 158.18

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