Nope - it's working on just about everything these days.

Some are coming with Beryl ready to go like Sabayon.  Others like Knoppix you'll have to grab it from the repos. 

Sabayon is a really sweet system based on Gentoo  and you can run beryl in live disc mode*
~Karlie

*Live disc - the entire OS runs from the CD/DVD.  Pop the disc in the drive.  Turn your computer on.  The OS will begin to boot.  Do what you like.  When you re-boot your computer without the Live disc in the drive you'll be right back to what you were using before - no changes will have been made and nothing installed.  Sort of like taking a new car out for a test drive to see if you like it.