Just to throw my two cents in.... 

I have a custom intel 2.66 dual core with 4gigs of ram, running Vista Home Premium.  I can definitely say Vue6I wants to be run in administrator mode - actually, it's the only mode that will launch the program for me. It's strange because I didn't have to launch as administrator when I first installed Vue (from the cd),  but after one of the upgrades ( I don't remeber which one) I can only access the program as administrator.  Other than that, I haven't had any issues with Vue and Vista.