Not anything different from waht you're doing I don't think.

I save out from Vue as png, usually 800K to 1.5M depending on what it is, I take it into CS3 and after making my adjustments re-save it as jpg at max.
For uploading here it's still too big so then I do a "save to web" in CS3 and usually save it as high or very high again depending on what I can get away with!

I don't lose quality doing it this way and I'm not really sure where you're losing it, can you give more detail about how you're going about it??

Injustice will be avenged.
Cofiwch Dryweryn.